RESUMEN
We report a 3-year-old girl with a delayed nontuberculous granulomatous reaction on a bacillus Calmette-Guérin injection site with dissemination to distant sites who showed a favorable response to clarithromycin used for 12 weeks with no recurrence on a follow-up of more than 2 years.
Asunto(s)
Antibacterianos/uso terapéutico , Vacuna BCG/efectos adversos , Claritromicina/uso terapéutico , Granuloma/inducido químicamente , Granuloma/tratamiento farmacológico , Preescolar , Femenino , HumanosRESUMEN
Phacomatosis pigmentovascularis is a rare group of syndromes characterized by the co-existence of a vascular nevus and a pigmentary nevus with or without extracutaneous systemic involvement. The existing classifications of phacomatosis pigmentovascularis are based on phenotypic characteristics. We report four new cases of phacomatosis pigmentovascularis, three with phacomatosis cesioflammea demonstrating phenotypic variability, and one with phacomatosis cesiomarmorata. Extracutaneous manifestations were observed in three patients (75%) that included central nervous system involvement in three, bilateral congenital glaucoma in two, and cardiovascular system involvement in one. The molecular basis of phacomatosis pigmentovascularis is yet to be elucidated. Whether the various subtypes of phacomatosis pigmentovascularis are separate molecular entities or phenotypic variants of the same disease needs to be settled.
Asunto(s)
Síndromes Neurocutáneos/diagnóstico por imagen , Femenino , Humanos , Lactante , Síndromes Neurocutáneos/terapiaRESUMEN
A female patient had Ehlers-Danlos syndrome type II since infancy, manifesting with hyperextensible skin and ciagarette paper scars at the sites of trauma. Treatment with vitamin C 1 gm a day seemed to be useful.
RESUMEN
In a patient with extensive, bilateral fixed drug eruption the offending drug was confirmed by provocation to be oxyphenbutazone with a cross reactivity with phenylbutazone.